Prevalence and Antimicrobial Resistance of Bloodstream Infections Caused by ESKAPEEc Pathogens: A Five-Year Analysis

Background: Antimicrobial resistance in ESKAPEEc (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and Escherichia coli) pathogens causing bloodstream infections is a growing threat to clinicians public health. Objectives: Our purpose was determine the prevalence susceptibility of ESKAPEEcs infection over five years (2016 2020) at large tertiary hospital Istanbul, Turkey. Methods: Of 2591 unique isolates obtained from blood culture specimens, 1.281 (49.4%) were positive for pathogens. The rates increased 2016 2019 decreased during COVID-19 pandemic. Results: most common pathogen K. pneumoniae (34.3%). Carbapenem resistant 61.8% A. baumannii 90.4%. percentages methicillin-resistant S. aureus vancomycin-resistant E. faecium 38.6% 29.4%, respectively. Conclusions: findings showed high incidence antimicrobial infections. Antibiotic policies restrictions health care settings community will play an essential role solution future.